Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery

Kun Xi; Yong Gu; Jincheng Tang; Hao Chen; Yun Xu; Liang Wu; Feng Cai; Lianfu Deng; Huilin Yang; Qin Shi; Wenguo Cui; Liang Chen

doi:10.1038/s41467-020-18265-3

Nature Communications (Sep 2020)

Microenvironment-responsive immunoregulatory electrospun fibers for promoting nerve function recovery

Kun Xi,
Yong Gu,
Jincheng Tang,
Hao Chen,
Yun Xu,
Liang Wu,
Feng Cai,
Lianfu Deng,
Huilin Yang,
Qin Shi,
Wenguo Cui,
Liang Chen

Affiliations

Kun Xi: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University
Yong Gu: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University
Jincheng Tang: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University
Hao Chen: Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Yun Xu: Shanghai Public Health Clinical Center, Fudan University
Liang Wu: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University
Feng Cai: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University
Lianfu Deng: Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Huilin Yang: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University
Qin Shi: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University
Wenguo Cui: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University
Liang Chen: Department of Orthopedics, the First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University

DOI: https://doi.org/10.1038/s41467-020-18265-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 18

Abstract

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Inflammatory responses determine the pathological course of spinal cord injury. Here, the authors report on pH responsive fibers for triggered release of IL-4 plasmid liposomes and sustained release of nerve growth factor to regulate the immune response and promote nerve regeneration to enhance functional recovery.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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