پزشکی بالینی ابن سینا (Dec 2001)
The Study of Relationship between Activity of Lichen Planus and Civatte Body
Abstract
Lichen Planus is an inflammatory disorder of skin and mucous membrane, with approximately unknown etiology and pathogenesis. From the clinical aspect, the disease is characterized by polygonal, purple, itchy and plan papules. Pathological changes are various in dermis and epidermis. One of those, is necrotic Keratinocyte or Civatte Body that seen in lower layer of epidermis and specially in upper layer of dermis. This investigation was a three years study of clinical and histopathological characteristics of Lichen Planus and relationship between response of Civatte body (Civ-b) and activity of the disease, in Sina hospital of Hamadan city (1995-98). This study was an analytic cross sectional study, and was performed by 106 files and microscopic slides of the patients affected by Lichen Planus. In this study, results showed that 75.8% of all dermis Civatte Body are in active phase of disease and this number is 88.2% for epidermis. The correlation between number of Civatte body and disease activity was statistically established by Fisher’s exact test (P value < 0.001). On the other hand, disease activity was also related to intensity of band from infiltration. Also results confirm that the more Civatte Body in dermis, the more epidermis Civatte Body. In this research, it was established that the more Civatte body, the more activity of Linchen planus and the decrease of Civatte Body shows decrease activity and relieve of disease.
