Can Natural Products be Used to Overcome the Limitations of Colorectal Cancer Immunotherapy?

Jiahuan Dong; Jiahuan Dong; Yufan Qian; Guangtao Zhang; Guangtao Zhang; Lu Lu; Shengan Zhang; Guang Ji; Aiguang Zhao; Hanchen Xu

doi:10.3389/fonc.2022.884423

Frontiers in Oncology (May 2022)

Can Natural Products be Used to Overcome the Limitations of Colorectal Cancer Immunotherapy?

Jiahuan Dong,
Jiahuan Dong,
Yufan Qian,
Guangtao Zhang,
Guangtao Zhang,
Lu Lu,
Shengan Zhang,
Guang Ji,
Aiguang Zhao,
Hanchen Xu

Affiliations

Jiahuan Dong: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Jiahuan Dong: Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yufan Qian: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Guangtao Zhang: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Guangtao Zhang: Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Lu Lu: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Shengan Zhang: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Guang Ji: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Aiguang Zhao: Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Hanchen Xu: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

DOI: https://doi.org/10.3389/fonc.2022.884423
Journal volume & issue: Vol. 12

Abstract

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Colorectal cancer (CRC) is a common cancer of the digestive system that endangers human health. Immunotherapy is widely used in the treatment of patients with cancer. Some patients with dMMR/MSI-H CRC benefit from treatments that use immune checkpoint inhibitors, but most CRC patients are not sensitive to immunotherapy. Furthermore, internal resistance and immune escape lead to a reduced immunotherapy response. Therefore, the development of an effective combination therapy to improve the response rate to immunotherapy is a goal of cancer research. Natural products are potential candidates for comprehensive cancer treatments due to their wide range of immunomodulatory effects through multifactorial underlying mechanisms. In this review, we summarize the challenges in the treatment of CRC and assess the immunomodulatory effects of natural products and their active components. Our work suggests that natural products represent potential options for combined CRC immunotherapy.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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