Endocrine Regulations (Oct 2019)

Hypoxic regulation of EDN1, EDNRA, EDNRB, and ECE1 gene expressions in ERN1 knockdown U87 glioma cells

  • Minchenko Dmytro O.,
  • Tsymbal Daria O.,
  • Riabovol Olena O.,
  • Viletska Yuliia M.,
  • Lahanovska Yuliia O.,
  • Sliusar Myroslava Y.,
  • Bezrodnyi Borys H.,
  • Minchenko Oleksandr H.

DOI
https://doi.org/10.2478/enr-2019-0025
Journal volume & issue
Vol. 53, no. 4
pp. 250 – 262

Abstract

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Objective. The aim of the present investigation was to study the effect of hypoxia on the expression of genes encoding endothelin-1 (EDN1) and its cognate receptors (EDNRA and EDNRB) as well as endothelin converting enzyme 1 (ECE1) in U87 glioma cells in response to inhibition of endoplasmic reticulum stress signaling mediated by ERN1/IRE1 (endoplasmic reticulum to nucleus signaling 1) for evaluation of their possible significance in the control of glioma growth through ERN1 and hypoxia.

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