Journal of Diabetes Investigation (2020-01-01)

Triglyceride to high‐density lipoprotein cholesterol ratio is associated with incident diabetes in men: A retrospective study of Chinese individuals

  • Hailun Qin,
  • Zekai Chen,
  • Yunzhang Zhang,
  • Lingyu Wang,
  • Piao Ouyang,
  • Lan Cheng,
  • Yonggang Zhang

Journal volume & issue
Vol. 11, no. 1
pp. 192 – 198


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Abstract Aims/Introduction Dyslipidemia is commonly present in type 2 diabetes mellitus patients. Recently, the triglyceride : high‐density lipoprotein cholesterol (TG/HDL‐C) ratio, a novel parameter of lipid abnormality, has been seen as an independent predictor for incident diabetes. However, the correlation of the TG/HDL‐C ratio with incident diabetes in the Chinese population and how this relationship is impacted by sex have been rarely studied. In the present study, the correlation of the TG/HDL‐C ratio with incident diabetes is investigated between different sexes of the Chinese population. Materials and Methods A total of 116,855 participants who were free of diabetes at baseline were enrolled in the study. The participants were grouped by the median value (0.82) of the TG/HDL‐C ratio. Then, participants were further analyzed according to their sex. Cumulative incidence and person‐years incidence were used to express the incidence rate. The predictive value of the TG/HDL‐C ratio for incident diabetes was probed by the Cox regression proportional hazards model. Results The mean age of the participants was 44.1 ± 12.9 years, and 53% of participants (n = 62,868) were the men. A total of 2,685 incident diabetes cases occurred during the 3.1 years of the median follow‐up period. The cumulative incidence in total incident diabetes patients, men and women was 2.30% (2.21–2.38%), 3.01% (2.87–3.14%) and 1.47% (1.37–1.57%), respectively. After the adjustment of multivariate factors, the multivariate Cox regression analysis results showed that a higher TG/HDL‐C ratio was the independent predictive factor of incident diabetes in men (hazard ratio 1.30, 95% confidence interval 1.03–1.64), compared with women (hazard ratio 0.85, 95% confidence interval 0.53–1.38). Conclusions Among the Chinese population, the TG/HDL‐C ratio is an independent predictor for incident diabetes in male patients.