miRNA in the Diagnosis and Treatment of Critical Limb Ischemia
Alexandra Ioana Popescu,
Andreea Luciana Rață,
Daliborca Vlad,
Cristian Vlad,
Roxana Popescu,
Ramona Roxana Onofrei,
Marialuisa Morelli,
Stelian Pantea,
Sorin Barac
Affiliations
Alexandra Ioana Popescu
Pharmacology Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Andreea Luciana Rață
Surgical Emergencies Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Daliborca Vlad
Pharmacology Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Cristian Vlad
Pharmacology Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Roxana Popescu
Cell and Molecular Biology Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Ramona Roxana Onofrei
Department of Rehabilitation, Physical Medicine and Rheumatology, Research Center for Assessment of Human Motion, Functionality and Disability, ”Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Marialuisa Morelli
Vascular Surgery Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Stelian Pantea
Surgical Emergencies Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Sorin Barac
Vascular Surgery Department, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Chronic threatening limb ischemia of the inferior limbs (CLTI) is the final stage of peripheral arterial disease (PAD) and is one of the most feared atherosclerotic manifestations because if left untreated, in time, it can lead to amputation. Although there are currently numerous treatment techniques, both open and endovascular, it is a pathology that has no underlying treatment. Therefore, current studies are very much focused on new therapeutic possibilities that can be applied in the early stages of the atherosclerotic process. In numerous studies in the literature, miRNAs have been identified as important markers of atherosclerosis. The present study aims to identify the expression of three miRNAs—miR-199a, miR-20a, and miR-30c—in patients with chronic limb-threatening ischemia in the pre- and post-revascularization periods. The aim of the study is to identify whether these three markers play a role in critical ischemia and whether they have the potential for future use in new treatments of this pathology.
