High-Dose Deltamethrin Induces Developmental Toxicity in <i>Caenorhabditis elegans</i> via IRE-1
Chuhong Chen,
Ying Deng,
Linyan Liu,
Zhenyan Zou,
Chenzhong Jin,
Zhiyin Chen,
Shuanghui Wang
Affiliations
Chuhong Chen
Key Laboratory of Green Control of Crop Pests in Hunan Higher Education, Hunan University of Humanities Science and Technology, Loudi 417000, China
Ying Deng
Key Laboratory of Green Control of Crop Pests in Hunan Higher Education, Hunan University of Humanities Science and Technology, Loudi 417000, China
Linyan Liu
Key Laboratory of Green Control of Crop Pests in Hunan Higher Education, Hunan University of Humanities Science and Technology, Loudi 417000, China
Zhenyan Zou
Collaborative Innovation Center for Farmland Weeds Control Techniques and Application of Hunan Province, Hunan University of Humanities Science and Technology, Loudi 417000, China
Chenzhong Jin
Key Laboratory of Green Control of Crop Pests in Hunan Higher Education, Hunan University of Humanities Science and Technology, Loudi 417000, China
Zhiyin Chen
Collaborative Innovation Center for Farmland Weeds Control Techniques and Application of Hunan Province, Hunan University of Humanities Science and Technology, Loudi 417000, China
Shuanghui Wang
Key Laboratory of Green Control of Crop Pests in Hunan Higher Education, Hunan University of Humanities Science and Technology, Loudi 417000, China
Deltamethrin (DM), a Type II pyrethroid, is widely used worldwide in agriculture, household applications, and medicine. Recent studies have shown that DM exerts a variety of toxic effects on organs such as the kidney, heart muscle, and nerves in animals. However, little is known about the effects of high-dose DM on growth and development, and the mechanism of toxicity remains unclear. Using the Caenorhabditis elegans model, we found that high-dose DM caused a delay in nematode development. Our results showed that high-dose DM reduced the activation of the endoplasmic reticulum unfolded protein response (UPRER). Further studies revealed that high-dose DM-induced developmental toxicity and reduced capacity for UPRER activation were associated with the IRE-1/XBP-1 pathway. Our results provide new evidence for the developmental toxicity of DM and new insights into the mechanism of DM toxicity.
