Nature Communications (Nov 2022)
Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes
- Timothy M. Moore,
- Lijing Cheng,
- Dane M. Wolf,
- Jennifer Ngo,
- Mayuko Segawa,
- Xiaopeng Zhu,
- Alexander R. Strumwasser,
- Yang Cao,
- Bethan L. Clifford,
- Alice Ma,
- Philip Scumpia,
- Orian S. Shirihai,
- Thomas Q. de Aguiar Vallim,
- Markku Laakso,
- Aldons J. Lusis,
- Andrea L. Hevener,
- Zhenqi Zhou
Affiliations
- Timothy M. Moore
- Division of Cardiology, Department of Medicine, University of California
- Lijing Cheng
- Division of Dermatology, Department of Medicine, University of California
- Dane M. Wolf
- Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California
- Jennifer Ngo
- Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California
- Mayuko Segawa
- Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California
- Xiaopeng Zhu
- Division of Pediatric Endocrinology, Department of Pediatrics UCLA Children’s Discovery and Innovation Institute, University of California
- Alexander R. Strumwasser
- Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California
- Yang Cao
- Division of Cardiology, Department of Medicine, University of California
- Bethan L. Clifford
- Division of Cardiology, Department of Medicine, University of California
- Alice Ma
- Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California
- Philip Scumpia
- Division of Dermatology, Department of Medicine, University of California
- Orian S. Shirihai
- Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California
- Thomas Q. de Aguiar Vallim
- Division of Cardiology, Department of Medicine, University of California
- Markku Laakso
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland
- Aldons J. Lusis
- Division of Cardiology, Department of Medicine, University of California
- Andrea L. Hevener
- Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California
- Zhenqi Zhou
- Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California
- DOI
- https://doi.org/10.1038/s41467-022-34468-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Parkin plays a role in mitophagy and has been shown to control adipose tissue browning and thermogenesis. Here the authors report that Parkin coordinates mitophagy with Pgc1α-mediated mitochondrial biogenesis in white adipocytes to regulate adiposity.
