Hydrogen–Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling

• Adam R. Offenbacher,
• Shenshen Hu,
• Erin M. Poss,
• Cody A. M. Carr,
• Alexander D. Scouras,
• Daniil M. Prigozhin,
• Anthony T. Iavarone,
• Ali Palla,
• Tom Alber,
• James S. Fraser,
• Judith P. Klinman

Affiliations

Adam R. Offenbacher

Department of Chemistry, University of California, Berkeley, California, United States

Shenshen Hu

Department of Chemistry, University of California, Berkeley, California, United States

Erin M. Poss

Department of Bioengineering and Therapeutic Science, University of California, San Francisco, San Francisco, California, United States

Cody A. M. Carr

Department of Chemistry, University of California, Berkeley, California, United States

Alexander D. Scouras

California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, California, United States

Daniil M. Prigozhin

California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, California, United States

Anthony T. Iavarone

Department of Chemistry, University of California, Berkeley, California, United States

Ali Palla

Department of Chemistry, University of California, Berkeley, California, United States

Tom Alber

California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, California, United States

James S. Fraser

Department of Bioengineering and Therapeutic Science, University of California, San Francisco, San Francisco, California, United States

Judith P. Klinman

Department of Chemistry, University of California, Berkeley, California, United States