Nature Communications (Mar 2017)

Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome

  • Florian Douam,
  • Gabriela Hrebikova,
  • Yentli E. Soto Albrecht,
  • Julie Sellau,
  • Yael Sharon,
  • Qiang Ding,
  • Alexander Ploss

DOI
https://doi.org/10.1038/ncomms14781
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 17

Abstract

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Analysis of virus replication on a single-cell level is often hampered by a lack of specific or sensitive enough reagents. Here, Douamet al. use RNA-flow technique to track (+) and (−) strand RNA of yellow fever virus in hematopoietic cells in mouse models and identify virus-host interactions that affect disease outcome.