Репродуктивная эндокринология (Oct 2019)

Pathogenetic substantiation of advantages and duration of phytoselective therapy of the menstrual cycle disorders

  • О. В. Грищенко,
  • В. В. Бобрицкая

DOI
https://doi.org/10.18370/2309-4117.2019.48.13-21
Journal volume & issue
Vol. 0, no. 48
pp. 13 – 21

Abstract

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One of the urgent modern problems is determining the optimal medicine for treatment of menstrual irregularities and duration of therapy. Objective of the study was to determine the optimal treatment period of menstrual irregularities with TazalokTM, as well as the comparative effectiveness of the therapy results with a derivative drug of Vitex agnus-castus. Design: a comparative study. Materials and methods. Analysis of retrospective data and dynamic observation of 120 patients 23–37 years old with menstrual irregularities who received monotherapy with TazalokTM and Vitex agnus castus was carried out. 60 patients received drugs for 3 months (group I TazalokTM and group II Vitex agnus-castus), and 60 patients for 6 months (group III TazalokTM and group IV Vitex agnus-castus). Groups are divided into subgroups depending on the menstruation nature: A – heavy, B – meager menstruation. All patients underwent a hormonal examination after 6 months (the results of the previous three-month therapy were considered initial), sonographic study, and dynamics of the pain syndrome were assessed according to the visual analogue scale. Study results. Subgroups IIIA and IIIB (TazalokTM for 6 months) showed the best clinical results and data from hormonal tests, sonography of the pelvic organs, mammary glands, thyroid gland; elimination of pain. An increase in progesterone levels, normalization of estradiol levels, follicle-stimulating hormone, and luteinizing hormone has been observed. Normalization of thyroid function was found in patients taking TazalokTM. Groups IVA and IVB (Vitex agnus-castus for 6 months) showed mainly a decrease in prolactin levels, normalization of mammary echography. The advantage of TazalokTM using also consisted in cortisol normalizing, one of the main pathogenetic factors for menstrual irregularities. Conclusion. TazalokTM is the drug of choice for monotherapy of menstrual irregularities, demonstrates the advantages of hormonal and clinical correction of pathological conditions in relation to Vitex agnus-castus; the 6 months treatment period should be considered optimal.

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