Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells

Stephanie Downs-Canner; Sara Berkey; Greg M. Delgoffe; Robert P. Edwards; Tyler Curiel; Kunle Odunsi; David L. Bartlett; Nataša Obermajer

doi:10.1038/ncomms14649

Nature Communications (Mar 2017)

Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells

Stephanie Downs-Canner,
Sara Berkey,
Greg M. Delgoffe,
Robert P. Edwards,
Tyler Curiel,
Kunle Odunsi,
David L. Bartlett,
Nataša Obermajer

Affiliations

Stephanie Downs-Canner: Department of Surgical Oncology, University of Pittsburgh
Sara Berkey: Department of Surgical Oncology, University of Pittsburgh
Greg M. Delgoffe: University of Pittsburgh Cancer Institute
Robert P. Edwards: University of Pittsburgh Cancer Institute
Tyler Curiel: UT Health Science Center at San Antonio
Kunle Odunsi: Departments of Gynecologic Oncology and Immunology, Roswell Park Cancer Institute
David L. Bartlett: Department of Surgical Oncology, University of Pittsburgh
Nataša Obermajer: Department of Surgical Oncology, University of Pittsburgh

DOI: https://doi.org/10.1038/ncomms14649
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

Th17 cells can transdifferentiate into regulatory T (Treg) cells. Here the authors characterize tumour-driven Th17-to-Tregcell transdifferentiation and identify potential cancer therapy targets.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal