Challenging the obesity paradox: extreme obesity and COPD mortality in the SUMMIT trial

Emily P. Brigham; Julie A. Anderson; Robert D. Brook; Peter M.A. Calverley; Bartolome R. Celli; Nicholas J. Cowans; Courtney Crim; James E. Diserens; Fernando J. Martinez; Meredith C. McCormack; David E. Newby; Julie Yates; Jorgen Vestbo; Tianshi David Wu; Robert A. Wise

doi:10.1183/23120541.00902-2020

ERJ Open Research (Jul 2021)

Challenging the obesity paradox: extreme obesity and COPD mortality in the SUMMIT trial

Emily P. Brigham,
Julie A. Anderson,
Robert D. Brook,
Peter M.A. Calverley,
Bartolome R. Celli,
Nicholas J. Cowans,
Courtney Crim,
James E. Diserens,
Fernando J. Martinez,
Meredith C. McCormack,
David E. Newby,
Julie Yates,
Jorgen Vestbo,
Tianshi David Wu,
Robert A. Wise

Affiliations

Emily P. Brigham: Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, MD, USA
Julie A. Anderson: Research and Development, GlaxoSmithKline, Stockley Park, UK
Robert D. Brook: Division of Cardiovascular Diseases, Wayne State University, Detroit, MI, USA
Peter M.A. Calverley: Dept of Medicine, Clinical Sciences Centre, University of Liverpool, University Hospital Aintree, Liverpool, UK
Bartolome R. Celli: Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Nicholas J. Cowans: Statistics and Programming, Veramed Ltd, Twickenham, UK
Courtney Crim: Research and Development, GlaxoSmithKline, Research Triangle Park, NC, USA
James E. Diserens: Statistics and Programming, Veramed Ltd, Twickenham, UK
Fernando J. Martinez: Division of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, NY, USA
Meredith C. McCormack: Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, MD, USA
David E. Newby: Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
Julie Yates: Research and Development, GlaxoSmithKline, Research Triangle Park, NC, USA
Jorgen Vestbo: Division of Infection, Immunity and Respiratory Medicine, Manchester Academic Health Sciences Centre, The University of Manchester and Manchester University NHS Foundation Trust, Manchester, UK
Tianshi David Wu: Section of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of Medicine, Houston, TX, USA
Robert A. Wise: Division of Pulmonary and Critical Care Medicine, Johns Hopkins Medicine, Baltimore, MD, USA

DOI: https://doi.org/10.1183/23120541.00902-2020
Journal volume & issue: Vol. 7, no. 3

Abstract

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Populations with COPD demonstrate higher survival in overweight and obese compared with normal weight; the “obesity paradox”. Relationships in less-severe COPD are unclear, as is the impact of cardiovascular risk, and few studies include individuals at extremes of obesity. We examined the relationship between body mass index (BMI; defined as underweight: 40 kg·m−2, suggesting that obesity may not remain protective at the extremes in this population.

Published in ERJ Open Research

ISSN: 2312-0541 (Online)
Publisher: European Respiratory Society
Country of publisher: United Kingdom
LCC subjects: Medicine
Website: https://openres.ersjournals.com/

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