Metabolic Pathways in Hydrocephalus: Profiling with Proteomics and Advanced Imaging

Abstract

Hemorrhagic hydrocephalus is a common pathology in neonates with high mortality and morbidity. Current imaging approaches fail to capture the mechanisms behind its pathogenesis. Here, we discuss the processes underlying this pathology, the metabolic dysfunction that occurs as a result, and the ways in which these metabolic changes inform novel methods of clinical imaging. The imaging advances described allow earlier detection of the cellular and metabolic changes, leading to better outcomes for affected neonates.

Keywords

• hydrocephalus
• contrast-enhanced ultrasound
• proteomics
• super-resolution imaging