Nature Communications (Jul 2021)

Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation

  • Gabriel Demo,
  • Howard B. Gamper,
  • Anna B. Loveland,
  • Isao Masuda,
  • Christine E. Carbone,
  • Egor Svidritskiy,
  • Ya-Ming Hou,
  • Andrei A. Korostelev

DOI
https://doi.org/10.1038/s41467-021-24911-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Translational frameshifting is a mechanism that expands the coding capabilities of mRNA. Here, structures of 70S ribosome complexes with GTPase elongation factor G (EF-G), a +1-frameshifting-prone mRNA and tRNAs reveal the cooperation between the ribosome and EF-G to induce +1 frameshifting during the translocation step.