Molecules
(Dec 2023)
Reconstructive Methodology in the Synthesis of 2-Aminopurine
Artyom O. Neymash,
Evgeny N. Ulomsky,
Victor V. Fedotov,
Semen V. Aminov,
Daniil N. Lyapustin,
Evgeny B. Gorbunov,
Vladislav A. Ishimnikov,
Pavel A. Slepukhin,
Vladimir L. Rusinov
Affiliations
Artyom O. Neymash
Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia
Evgeny N. Ulomsky
Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia
Victor V. Fedotov
Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia
Semen V. Aminov
Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia
Daniil N. Lyapustin
Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia
Evgeny B. Gorbunov
Institute of Organic Synthesis, Ural Branch of the Russian Academy of Science, Sofii Kovalevskoy St. 22, 620137 Yekaterinburg, Russia
Vladislav A. Ishimnikov
Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia
Pavel A. Slepukhin
Institute of Organic Synthesis, Ural Branch of the Russian Academy of Science, Sofii Kovalevskoy St. 22, 620137 Yekaterinburg, Russia
Vladimir L. Rusinov
Chemical Engineering Institute, Ural Federal University, 19 Mira St., 620002 Yekaterinburg, Russia
DOI
https://doi.org/10.3390/molecules29010134
Journal volume & issue
Vol. 29,
no. 1
Abstract
Read online
A fundamentally new synthetic approach to the synthesis of 2-aminopurine has been developed. It consists in the combination of the creation of a condensed polyazotic heterocyclic tetrazolopyrimidine structure, its transformation into triaminopyrimidine, and its subsequent cyclization into 2-aminopurine. The structure of the obtained compounds was established based on spectral characteristics, and the structure of the intermediate compound 5 was established directly by X-ray diffraction analysis.
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