AMPA receptor anchoring at CA1 synapses is determined by N-terminal domain and TARP γ8 interactions

Abstract

Changes in AMPAR localization can control the strength of synaptic transmission. Here, the authors show that the interactions of TARP γ8 and the AMPAR N-terminal domain work together to regulate receptor accumulation and positioning at the post-synapse of mouse hippocampal CA1 neurons.