A framework for dissecting affinities of multidrug efflux transporter AcrB to fluoroquinolones

Julia Vergalli; Hugo Chauvet; Francesco Oliva; Jelena Pajović; Giuliano Malloci; Attilio Vittorio Vargiu; Matthieu Réfrégiers; Paolo Ruggerone; Jean-Marie Pagès

doi:10.1038/s42003-022-04024-1

Communications Biology (Oct 2022)

A framework for dissecting affinities of multidrug efflux transporter AcrB to fluoroquinolones

Julia Vergalli,
Hugo Chauvet,
Francesco Oliva,
Jelena Pajović,
Giuliano Malloci,
Attilio Vittorio Vargiu,
Matthieu Réfrégiers,
Paolo Ruggerone,
Jean-Marie Pagès

Affiliations

Julia Vergalli: UMR_MD1, U-1261, Aix-Marseille Univ, INSERM, IRBA, MCT
Hugo Chauvet: DISCO beamline, Synchrotron Soleil
Francesco Oliva: Department of Physics, University of Cagliari
Jelena Pajović: DISCO beamline, Synchrotron Soleil
Giuliano Malloci: Department of Physics, University of Cagliari
Attilio Vittorio Vargiu: Department of Physics, University of Cagliari
Matthieu Réfrégiers: DISCO beamline, Synchrotron Soleil
Paolo Ruggerone: Department of Physics, University of Cagliari
Jean-Marie Pagès: UMR_MD1, U-1261, Aix-Marseille Univ, INSERM, IRBA, MCT

DOI: https://doi.org/10.1038/s42003-022-04024-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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A competitive efflux assay combined with computational approaches reveal how different quinolones interact with the prototypical bacterial multidrug efflux transporter AcrB, providing insights which may help optimise antibiotics.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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