Nature Communications (Mar 2022)
Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion
- Nian Jiang,
- Bowen Xie,
- Wenwu Xiao,
- Ming Fan,
- Shanxiu Xu,
- Yixin Duan,
- Yamah Hamsafar,
- Angela C. Evans,
- Jie Huang,
- Weibing Zhou,
- Xuelei Lin,
- Ningrong Ye,
- Siyi Wanggou,
- Wen Chen,
- Di Jing,
- Ruben C. Fragoso,
- Brittany N. Dugger,
- Paul F. Wilson,
- Matthew A. Coleman,
- Shuli Xia,
- Xuejun Li,
- Lun-Quan Sun,
- Arta M. Monjazeb,
- Aijun Wang,
- William J. Murphy,
- Hsing-Jien Kung,
- Kit S. Lam,
- Hong-Wu Chen,
- Jian Jian Li
Affiliations
- Nian Jiang
- Department of Radiation Oncology, University of California Davis School of Medicine
- Bowen Xie
- Department of Radiation Oncology, University of California Davis School of Medicine
- Wenwu Xiao
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Ming Fan
- Department of Radiation Oncology, University of California Davis School of Medicine
- Shanxiu Xu
- Department of Surgery, School of Medicine, University of California Davis
- Yixin Duan
- Department of Radiation Oncology, University of California Davis School of Medicine
- Yamah Hamsafar
- Department of Pathology and Laboratory Medicine, University of California Davis
- Angela C. Evans
- Department of Radiation Oncology, University of California Davis School of Medicine
- Jie Huang
- Department of Radiation Oncology, University of California Davis School of Medicine
- Weibing Zhou
- Department of Radiation Oncology, University of California Davis School of Medicine
- Xuelei Lin
- Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University
- Ningrong Ye
- Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University
- Siyi Wanggou
- Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University
- Wen Chen
- Department of Radiation Oncology, University of California Davis School of Medicine
- Di Jing
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Ruben C. Fragoso
- Department of Radiation Oncology, University of California Davis School of Medicine
- Brittany N. Dugger
- Department of Pathology and Laboratory Medicine, University of California Davis
- Paul F. Wilson
- Department of Radiation Oncology, University of California Davis School of Medicine
- Matthew A. Coleman
- Department of Radiation Oncology, University of California Davis School of Medicine
- Shuli Xia
- Department of Neurology, Johns Hopkins School of Medicine
- Xuejun Li
- Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University
- Lun-Quan Sun
- Center for Molecular Medicine, Xiangya Hospital, Central South University
- Arta M. Monjazeb
- Department of Radiation Oncology, University of California Davis School of Medicine
- Aijun Wang
- Department of Surgery, School of Medicine, University of California Davis
- William J. Murphy
- NCI-Designated Comprehensive Cancer Center, University of California Davis
- Hsing-Jien Kung
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Kit S. Lam
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Hong-Wu Chen
- Department of Biochemistry and Molecular Medicine, University of California Davis
- Jian Jian Li
- Department of Radiation Oncology, University of California Davis School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-29137-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Acquired radioresistance is a challenge for the cure of glioblastoma. Here, the authors show that radioresistant glioblastoma boosts mitochondrial fatty acid oxidation that fuels cell proliferation and induces immunosuppression via CD47 mediated anti-phagocytosis. Inhibition of FAO by etomoxir combined with anti-CD47 antibodies sensitizes glioblastoma to radiotherapy.
