مجلة كلية الطب (Jan 2010)

Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus.

  • Sajid N. Abdualkader,
  • Abdul- Wahab Al-Shaikly,
  • Khalida M. Al-Mousawy,
  • Mustafa Al-Ezzi,
  • Maan G. Hasso,
  • Zena E. Hassan

DOI
https://doi.org/10.32007/jfacmedbagdad.v4416-418%
Journal volume & issue
Vol. 51, no. 4

Abstract

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Background: There is a general acceptance which illustrated that auto antibodies act as a central immunological disturbance in most of the auto immune diseases, among these auto immune diseaselies the SLE Patients and Methods: Thirty five patients with SLE were compared to twenty age and sex matched, control subjects and studied for the presence of auto antibodies, plus IL-4 and IL-6 using Elisa method and immune fluorescent method (for ANA only) Results: Data showed that IL-6 detectable levels were statistically significant in patients with positive anti ds-DNA, but not significant statistically in ANA positive patients although it was detected in 24 (70.6%) of positive ANA patients, while there was no statistically significant correlation between IL- 4 detectable level and autoantibodies production. Conclusion: There is apparently a positive correlation between IL-6 and anti ds DNA production in lupus patients.

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