Pre-metastatic Niche Formation in Different Organs Induced by Tumor Extracellular Vesicles

Qi Dong; Qi Dong; Qi Dong; Xue Liu; Xue Liu; Ke Cheng; Jiahao Sheng; Jing Kong; Tingjiao Liu; Tingjiao Liu

doi:10.3389/fcell.2021.733627

Frontiers in Cell and Developmental Biology (Sep 2021)

Pre-metastatic Niche Formation in Different Organs Induced by Tumor Extracellular Vesicles

Qi Dong,
Qi Dong,
Qi Dong,
Xue Liu,
Xue Liu,
Ke Cheng,
Jiahao Sheng,
Jing Kong,
Tingjiao Liu,
Tingjiao Liu

Affiliations

Qi Dong: Department of Basic Science of Stomatology, Shanghai Stomatological Hospital, Fudan University, Shanghai, China
Qi Dong: Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China
Qi Dong: Department of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian, China
Xue Liu: Department of Basic Science of Stomatology, Shanghai Stomatological Hospital, Fudan University, Shanghai, China
Xue Liu: Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China
Ke Cheng: Department of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian, China
Jiahao Sheng: Department of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian, China
Jing Kong: Department of Oral Pathology, School of Stomatology, Dalian Medical University, Dalian, China
Tingjiao Liu: Department of Basic Science of Stomatology, Shanghai Stomatological Hospital, Fudan University, Shanghai, China
Tingjiao Liu: Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China

DOI: https://doi.org/10.3389/fcell.2021.733627
Journal volume & issue: Vol. 9

Abstract

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Primary tumors selectively modify the microenvironment of distant organs such as the lung, liver, brain, bone marrow, and lymph nodes to facilitate metastasis. This supportive metastatic microenvironment in distant organs was termed the pre-metastatic niche (PMN) that is characterized by increased vascular permeability, extracellular matrix remodeling, bone marrow-derived cells recruitment, angiogenesis, and immunosuppression. Extracellular vesicles (EVs) are a group of cell-derived membranous structures that carry various functional molecules. EVs play a critical role in PMN formation by delivering their cargos to recipient cells in target organs. We provide an overview of the characteristics of the PMN in different organs promoted by cancer EVs and the underlying mechanisms in this review.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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