2-methoxy-4-(((5-nitropyridin-2-yl)imino)methyl)phenol Schiff base ligand and its Cu(II) and Zn(II) complexes: synthesis, characterization and biological investigations
P. Deepika,
H.M. Vinusha,
Muneera Begum,
Ramith Ramu,
Prithvi S. Shirahatti,
M.N. Nagendra Prasad
Affiliations
P. Deepika
Department of Chemistry, JSS Science and Technology University, Mysuru, Karnataka, 570 006, India
H.M. Vinusha
PG Department of Chemistry, Sarada Vilas College, Mysuru, 570004, India
Muneera Begum
Department of Chemistry, JSS Science and Technology University, Mysuru, Karnataka, 570 006, India; Corresponding author.
Ramith Ramu
Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research (JSS AHER), Mysuru, 570015, India
Prithvi S. Shirahatti
Post Graduation Department of Biotechnology, Teresian College, Siddhartha Nagara, Mysuru, 570015, India
M.N. Nagendra Prasad
Department of Biotechnology, JSS Science and Technology University, JSS Technical Institutional Campus, Mysuru, Karnataka, 570006, India
In this current work we have prepared a Schiff base ligand, (HL) derived from 5- nitropyridine-2-amine with 4-hydroxy-3-methoxybenzaldehyde and its Cu(II), and Zn(II) in 2:1 stoichiometric ratio (2HL:M). The formation of the ligand and the metal complexes were evaluated by means of MS, FT-IR, UV-Visible, 1H-NMR, 13C-NMR and thermogravimetric methods. The free radical scavenging activity of compounds was evaluated through a sequence of in vitro assays viz., DPPH, ABTS and Superoxide where BHA was used as a positive controller. In vitro α-glucosidase inhibitory activities showed that complexes had considerable inhibitory potential when compared to the ligand.
