New family of tetrazole-pyrazole compounds: Synthesis, characterization, antimicrobial activity and docking study

Abstract

New pyrazole-tetrazole hybrid molecules were obtained via two synthetic pathways. The first one is equimolar condensation of N-alkylated pyrazole with 1H-tetrazolic derivatives (yields in range 31–45%) while in the second route consists in a direct alkylation of the pyrazole-tetrazole derivatives at the N2 position of the pyrazolic ring (yields in range 63–75%). The structure of these compounds was characterized by spectroscopic and spectrometric methods. The evaluation of the antimicrobial activity of these compounds against four bacterial and six fungal strains was performed and the obtained findings show that they possess a medium activity (inhibition zone diameter in the range of 9–19 mm) compared to the used positive controls. Furthermore, the antibacterial and antifungal activities were affected by the substituents on the tetrazole rings and junction position between the two N-heterocycles. Some experimental results are also supported by a docking study.

Keywords

• Antifungal activity
• Anbacterial activity
• Docking calculation
• Hybrid
• Pyrazole-tetrazole