Nature Communications (Jan 2019)
The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma
- Vivek Bhaskaran,
- Michal O. Nowicki,
- Mahmoud Idriss,
- Miguel A. Jimenez,
- Gianmarco Lugli,
- Josie L. Hayes,
- Ahmad Bakur Mahmoud,
- Rachel E. Zane,
- Carmela Passaro,
- Keith L. Ligon,
- Daphne Haas-Kogan,
- Agnieszka Bronisz,
- Jakub Godlewski,
- Sean E. Lawler,
- E. Antonio Chiocca,
- Pierpaolo Peruzzi
Affiliations
- Vivek Bhaskaran
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- Michal O. Nowicki
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- Mahmoud Idriss
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- Miguel A. Jimenez
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- Gianmarco Lugli
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- Josie L. Hayes
- School of Public Health, University of California, Berkeley
- Ahmad Bakur Mahmoud
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- Rachel E. Zane
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- Carmela Passaro
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- Keith L. Ligon
- Division of Neuro-Pathology, Department of Pathology, Brigham and Women’s Hospital
- Daphne Haas-Kogan
- Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute
- Agnieszka Bronisz
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- Jakub Godlewski
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- Sean E. Lawler
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- E. Antonio Chiocca
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- Pierpaolo Peruzzi
- Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Harvard Medical School and Brigham and Women’s Hospital
- DOI
- https://doi.org/10.1038/s41467-019-08390-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
The delivery of single therapeutic microRNAs in brain cancers is challenging. Here, the authors engineer three neuronal microRNAs (miR-124, 128 and 137) into a cluster that, targeting oncogenic chromatin repressors, increases survival of GBM-bearing mice when combined with chemotherapy.
