Mechanistic understanding of human SLFN11

Felix J. Metzner; Simon J. Wenzl; Michael Kugler; Stefan Krebs; Karl-Peter Hopfner; Katja Lammens

doi:10.1038/s41467-022-33123-0

Nature Communications (Sep 2022)

Mechanistic understanding of human SLFN11

Felix J. Metzner,
Simon J. Wenzl,
Michael Kugler,
Stefan Krebs,
Karl-Peter Hopfner,
Katja Lammens

Affiliations

Felix J. Metzner: Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München
Simon J. Wenzl: Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München
Michael Kugler: Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München
Stefan Krebs: Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München
Karl-Peter Hopfner: Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München
Katja Lammens: Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München

DOI: https://doi.org/10.1038/s41467-022-33123-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

Read online

Schlafen 11 serves as an antiviral restriction factor and a predictive biomarker in cancer. Here, the authors use cryoelectron microscopy and biochemical assays to understand tRNA endoribonuclease and DNA binding functions of human Schlafen 11.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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