Frontiers in Oncology (Aug 2023)

Nodular cutaneous metastasis of the leg in advanced urothelial bladder carcinoma: a case report and systematic literature review

  • Paolo Izzo,
  • Luciano Izzo,
  • Silvia Lai,
  • Giuliano D’Onghia,
  • Paola Giancontieri,
  • Raimondo Gabriele,
  • Andrea Polistena,
  • Simone Sibio,
  • Maria Ludovica Costanzo,
  • Claudia De Intinis,
  • Sara Izzo

DOI
https://doi.org/10.3389/fonc.2023.1216725
Journal volume & issue
Vol. 13

Abstract

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Cutaneous metastases from urothelial carcinoma (UC) are very rare and indicate advanced disease with a poor prognosis. A 63-year-old female patient with a history of urothelial bladder carcinoma, treated 2 months prior with radical cystectomy and adjuvant gemcitabine and cisplatin (GC) therapy, presented a skin lesion localized in the lower third of the right leg. Punch biopsy revealed carcinomatous metastasis whose urothelial origin was confirmed by immunohistochemical analysis. 18-FDG PET-CT showed the spread of metastases to the lung and left ischium. Our review focuses on the time between surgery and skin metastasis, localization, and prognosis after metastasis diagnosis. In many cases, skin metastases occur within one year of initial UC surgery and in most cases occur on the abdominal wall. Local wide excision of metastasis should be considered in selected cases; however, chemotherapy remains the main treatment.

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