Frontiers in Medicine (Jul 2024)
Associations of different inflammatory factors with atherosclerosis among patients with psoriasis vulgaris
Abstract
BackgroundThis study aimed to measure the associations between different inflammatory factors, namely interleukin (IL)-17A, tumor necrosis factor (TNF)-α, and high-sensitivity C-reactive protein (hs-CRP), and atherosclerosis in patients with psoriasis vulgaris.MethodsA cross-sectional study was conducted at two hospitals in Hanoi, Vietnam. A total of 125 patients with psoriasis vulgaris and 50 healthy controls were recruited. Clinical characteristics and atherosclerosis were assessed. IL-17A, TNF-α, and hs-CRP levels were measured.ResultsPsoriasis vulgaris patients with atherosclerosis had higher levels of hs-CRP (median = 1.22; interquartile range—IQR = 0.34–12.11) and IL-17A (median = 1.30; IQR = 0.43–4.28), but a lower level of TNF-α (median = 0.54; IQR = 0.13–3.41) compared to those without atherosclerosis (p < 0.05). Only LogIL-17A was positively related to atherosclerosis in psoriasis patients (Odds Ratio—OR = 2.16, 95% CI = 1.06–4.38, p < 0.05). After excluding systemically treated patients, LogIL-17A and Log TNF-α were associated with the likelihood of atherosclerosis (p < 0.05).ConclusionThis study suggests a link between elevated levels of IL-17A and TNF-α and subclinical atherosclerosis. Further investigation on a larger scale is required to establish the causality of this relationship.
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