Türk Kardiyoloji Derneği Arşivi (Jan 2017)

Relationship between serum osteopontin level and atrial fibrillation recurrence in patients undergoing cryoballoon catheter ablation

  • Hacı Murat Güneş,
  • Gamze Babur Güler,
  • Ekrem Güler,
  • Gültekin Günhan Demir,
  • Filiz Kızılırmak Yılmaz,
  • Mehmet Onur Omaygenç,
  • Ayşe İstanbullu Tosun,
  • Taylan Akgün,
  • Bilal Boztosun,
  • Fethi Kılıçarslan

DOI
https://doi.org/10.5543/tkda.2016.21855
Journal volume & issue
Vol. 45, no. 1
pp. 26 – 32

Abstract

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Objective: Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with increased morbidity and mortality. Atrial fibrosis augments recurrence rate following AF catheter ablation. Osteopontin is a multifunctional molecule involved in several pathophysiological pathways, including fibrosis. Presently described is investigation of relationship between serum osteopontin level and AF recurrence after AF cryoablation. Methods: The study was designed to be prospective and observational; 60 patients with paroxysmal (n=47) and persistent (n=13) AF were included. Osteopontin level was measured both before and 6 months after AF ablation with cryoballoon. Results: Preprocedure and postprocedure osteopontin level did not differ between the 2 groups of AF patients (p=0.286, p=0.493, respectively). Postprocedure osteopontin level was significantly higher compared with preprocedure value (32.18 ng/mL vs 15.58 ng/mL; p=<0.001). Left atrial diameter, AF type, and preprocedure osteopontin level were related to AF recurrence (p≤0.05). An age-adjusted multivariate logistic regression analysis was conducted to determine independent predictors of AF recurrence. Among these, AF type (β=2.211; p=0.004; odds ratio [OR]: 9.124; 95% confidence interval [CI]: 2.026–41.094) was found to be the most important factor related to AF recurrence. Preprocedure osteopontin level also predicted AF recurrence independently (β=0.059; p=0.048; OR: 1.061; 95% CI 1.001–1.125). Conclusion: Study results revealed persistency of AF and high preprocedure osteopontin level independently predicted AF recurrence in patients undergoing cryoballoon AF ablation. Association of a biochemical marker with AF recurrence might be beneficial to selection of appropriate patients for cryoballoon procedure and assessment of long-term procedural success.

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