Laminar shear stress inhibits inflammation by activating autophagy in human aortic endothelial cells through HMGB1 nuclear translocation

Qingyu Meng; Luya Pu; Mingran Qi; Shuai Li; Banghao Sun; Yaru Wang; Bin Liu; Fan Li

doi:10.1038/s42003-022-03392-y

Communications Biology (May 2022)

Laminar shear stress inhibits inflammation by activating autophagy in human aortic endothelial cells through HMGB1 nuclear translocation

Qingyu Meng,
Luya Pu,
Mingran Qi,
Shuai Li,
Banghao Sun,
Yaru Wang,
Bin Liu,
Fan Li

Affiliations

Qingyu Meng: Department of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University
Luya Pu: Department of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University
Mingran Qi: Department of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University
Shuai Li: Department of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University
Banghao Sun: Department of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University
Yaru Wang: Department of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University
Bin Liu: Cardiovascular Disease Center, The First Hospital of Jilin University
Fan Li: Department of Pathogenobiology, The Key Laboratory of Zoonosis, Chinese Ministry of Education, College of Basic Medicine, Jilin University

DOI: https://doi.org/10.1038/s42003-022-03392-y
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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The transcriptional response to laminar sheer stress in human aortic endothelial cells reveals a pathway leading to inhibition of endothelial cell inflammation by autophagy induction.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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