Practical Laboratory Medicine (Jan 2019)
Biological function and molecular mechanism of piRNA in cancer
- Ghanbar Mahmoodi Chalbatani,
- Hassan Dana,
- Feridon Memari,
- Elahe Gharagozlou,
- Shirin Ashjaei,
- Peyman Kheirandish,
- Vahid Marmari,
- Habibollah Mahmoudzadeh,
- Farnaz Mozayani,
- Ali Reza Maleki,
- Ehsan Sadeghian,
- Elham Zainali Nia,
- Seyed Rohollah Miri,
- Neda zainali Nia,
- Omid Rezaeian,
- Anahita Eskandary,
- Narges Razavi,
- Mohammad Shirkhoda,
- Fatemeh Nouri Rouzbahani
Affiliations
- Ghanbar Mahmoodi Chalbatani
- Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
- Hassan Dana
- Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
- Feridon Memari
- Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
- Elahe Gharagozlou
- Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
- Shirin Ashjaei
- Department of Paramedical Sciences, Islamic Azad University, Tehran Branch, Tehran, Iran
- Peyman Kheirandish
- Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
- Vahid Marmari
- Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
- Habibollah Mahmoudzadeh
- Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
- Farnaz Mozayani
- Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
- Ali Reza Maleki
- Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
- Ehsan Sadeghian
- Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
- Elham Zainali Nia
- Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
- Seyed Rohollah Miri
- Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran; Corresponding authors.
- Neda zainali Nia
- Department of Biology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
- Omid Rezaeian
- Department of Biology, NourDanesh Institute of Higher Education, Isfahan, Iran
- Anahita Eskandary
- Department of Biology, NourDanesh Institute of Higher Education, Isfahan, Iran
- Narges Razavi
- Shahid Beheshti University of Medical Sciences, Tehran, Iran
- Mohammad Shirkhoda
- Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran; Corresponding authors.
- Fatemeh Nouri Rouzbahani
- Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Science, Tehran, Iran
- Journal volume & issue
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Vol. 13
Abstract
Cancer is the second leading cause of death globally. piRNAs, which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in cancer genomics. In recent years, a relatively large number of studies have demonstrated that several piRNA are aberrantly expressed in various kinds of cancers including gastric cancer, bladder cancer, breast cancer, colorectal cancer and Lung cancer and may probably serve as a novel therapeutic target and biomarker for cancer treatment. The present review summarized current advances in our knowledge of the roles of piRNAs in cancer. Keywords: Cancer, PiRNA, Noncoding RNA, Gene silencing, RNAi
