Synthesis of novel phosphorylated peptidomimetics which contain ω-haloalkyl and ω-thiocyanoethyl residues

Abstract

The interaction of (2-aryl-5-(hydroxyalkylamino)-1,3-oxazol-4-yl)phosphonates with hydrogen chloride, hydrogen iodide and hydrogen thiocyanate in anhydrous medium led to formation of new phosphorylated peptidomimetics containing C-terminal ω-haloalkyl and ω-thiocyanoethyl residues.

Keywords

• 1
• 3-oxazoles
• phosphonates
• phosphorylated peptidomimetics
• hydrogen halogenides
• hydrogen thiocyanate