Heterogeneous Metal–Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry
Daniele Cartagenova,
Stephan Bachmann,
Jereon A. van Bokhoven,
Kurt Püntener,
Marco Ranocchiari
Affiliations
Daniele Cartagenova
Paul Scherrer Institute, Laboratory for Catalysis and Sustainable Chemistry, Forschungsstrasse 111, CH-5232 Villigen PSI, Switzerland
Stephan Bachmann
F. Hoffmann-La Roche Ltd., Department of Process Chemistry & Catalysis, Grenzacherstrasse 124, CH-4070 Basel, Switzerland
Jereon A. van Bokhoven
Paul Scherrer Institute, Laboratory for Catalysis and Sustainable Chemistry, Forschungsstrasse 111, CH-5232 Villigen PSI, Switzerland; ETH Zurich, Institute for Chemical and Bioengineering, CH-8093 Zurich
Kurt Püntener
F. Hoffmann-La Roche Ltd., Department of Process Chemistry & Catalysis, Grenzacherstrasse 124, CH-4070 Basel, Switzerland
Marco Ranocchiari
Paul Scherrer Institute, Laboratory for Catalysis and Sustainable Chemistry, Forschungsstrasse 111, CH-5232 Villigen PSI, Switzerland
The synthesis of drug substances (DS) requires the continuous effort of the pharma industry to ensure high sustainability standards. The Suzuki-Miyaura cross coupling is a fundamental C–C bond-forming reaction to produce complex DS intermediates. The present contribution points out the way in which the synthesis of DS intermediates by C–C cross coupling can be economically competitive, while minimizing waste by selecting the appropriate heterogeneous catalyst. By comparing homogeneous, immobilized heterogeneous catalysts on silica and metal–organic framework (MOF) catalysts, while considering the perspectives of academia and industry, the critical parameters for a successful industrial application of heterogeneous catalytic Suzuki-Miyaura cross coupling reactions were identified. Heterogeneous catalysts, such as MOFs, may provide a complementary platform for reducing waste and the costs of production related to such transformations.
