Tigecycline resistance tet(X3) gene is going wild

Jian Cao; Jun Wang; Yanan Wang; Liang Wang; Yuhai Bi; Baoli Zhu; George Fu Gao

Biosafety and Health (Mar 2020)

Tigecycline resistance tet(X3) gene is going wild

Jian Cao,
Jun Wang,
Yanan Wang,
Liang Wang,
Yuhai Bi,
Baoli Zhu,
George Fu Gao

Affiliations

Jian Cao: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100052, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China
Jun Wang: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100052, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China
Yanan Wang: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100052, China
Liang Wang: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100052, China
Yuhai Bi: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100052, China
Baoli Zhu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100052, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China
George Fu Gao: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100052, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China; National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Corresponding author: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100052, China.

Journal volume & issue: Vol. 2, no. 1
pp. 9 – 11

Abstract

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The emergence of mobile Tigecycline-resistant tet(X3) and tet(X4) is believed to be a global threat to public health. Here, we investigated the prevalence of tet(X3) and tet(X4) in our metagenomic data of migratory birds. While tet(X4) was not identified in our samples, tet(X3) was found in two gut microbiomes of bird fecal samples, with 100% amino acid identity of sites 150–387. These results suggest that tet(X3) has been spreading into the environment for a long period of time and that there is an urgent need to control its further transmission.

Published in Biosafety and Health

ISSN: 2590-0536 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/biosafety-and-health/

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