Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in ChinaCapsule Summary

Minghui Wei, MM; Cheng Xie, MD, PhD; Yubo Liu, MM; Yuhong Wang, MM; Yuanyuan Wang, MM; Xinwen Wang, MD, PhD; Yuan Liu, MD, PhD

JAAD International (Dec 2020)

Characterizing disease manifestations and treatment outcomes among patients with orofacial granulomatosis in ChinaCapsule Summary

Minghui Wei, MM,
Cheng Xie, MD, PhD,
Yubo Liu, MM,
Yuhong Wang, MM,
Yuanyuan Wang, MM,
Xinwen Wang, MD, PhD,
Yuan Liu, MD, PhD

Affiliations

Minghui Wei, MM: Department of Oral Medicine, School of Stomatology, the Fourth Military Medical University, Xi'an, China; Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military Stomatology
Cheng Xie, MD, PhD: Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military Stomatology; Outpatient Department, School of Stomatology, the Fourth Military Medical University, Xi'an, China
Yubo Liu, MM: Department of Stomatology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, China
Yuhong Wang, MM: Department of Oral Medicine, School of Stomatology, the Fourth Military Medical University, Xi'an, China; Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military Stomatology
Yuanyuan Wang, MM: Department of Oral Medicine, School of Stomatology, the Fourth Military Medical University, Xi'an, China; Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military Stomatology
Xinwen Wang, MD, PhD: Department of Oral Medicine, School of Stomatology, the Fourth Military Medical University, Xi'an, China; Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military Stomatology; Correspondence to: Xinwen Wang, MD, PhD, or Yuan Liu, MD, PhD, Changle W Rd 145, Xi'an, 710032, Shaanxi Province, China.
Yuan Liu, MD, PhD: Shaanxi Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Disease of China, State Key Laboratory of Military Stomatology; Department of Pathology, School of Stomatology, the Fourth Military Medical University, Xi'an, China; Correspondence to: Xinwen Wang, MD, PhD, or Yuan Liu, MD, PhD, Changle W Rd 145, Xi'an, 710032, Shaanxi Province, China.

Journal volume & issue: Vol. 1, no. 2
pp. 126 – 134

Abstract

Read online

Background: Racial variation exists in the incidence of orofacial granulomatosis (OFG). The epidemiology and clinical characteristics of OFG in Asian countries are poorly described. Objective: To describe the epidemiologic and clinical features of OFG in China from data collected on chronic odontogenic infection and studied in actual practice regarding the long-term outcome of OFG patients receiving different treatments. Methods: Data on demographics, medical history, chronic odontogenic infection, and the extent of disease were collected, and long-term outcomes after the end of treatments were evaluated. Results: Of the 165 OFG patients, 118 (71.5%; 95% CI 64.6%-78.5%) had a chronic odontogenic infection. There was a variety of difference between OFG with and without chronic odontogenic infection. Approximately 98.3% (95% confidence interval 94.8%-100%) of OFG patients with chronic odontogenic infection who received dental treatment showed a marked response, of whom 31 patients (53.4%; 95% confidence interval 40.2%-66.7%) had complete remission. Limitations: Endoscopic investigations were not performed for most of the patients, and more detailed data were not collected, which might have demonstrated additional systemic problems. Conclusions: OFG with chronic odontogenic infection is the major clinical pattern of OFG in China, which may be a subtype of OFG. Dental treatment should necessarily be the preferred first-line therapy for such patients.

Published in JAAD International

ISSN: 2666-3287 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Dermatology
Website: https://www.journals.elsevier.com/jaad-international

About the journal

Abstract

Keywords