This paper aims to elucidate reflections of technological transition today through the ‘unity’ of living and manufactured components of building design. Technological advances enable living organisms from algae to humans, and many more, to become useful tools to create interior and structural elements for buildings. Thus, designing with living organisms has become a growing phenomenon in architecture by transforming building components into ‘biobuilding’ components. In this paper, this phenomenon is critiqued through the bonds between the concepts of nature, technology, and building design, from contemporary studies to the highlights back in history. Overall, the paper gives architects insights on the envisioned future that presents a harmony between natural and building environment.