Frontiers in Aging Neuroscience (Jan 2024)

Fish oil supplementation, physical activity and risk of incident Parkinson’s disease: results of longitudinal analysis from the UK Biobank

  • Fabin Lin,
  • Fabin Lin,
  • Fabin Lin,
  • Fabin Lin,
  • Fabin Lin,
  • Yisen Shi,
  • Yisen Shi,
  • Yisen Shi,
  • Yisen Shi,
  • Jiayi Zheng,
  • Jiayi Zheng,
  • Jiayi Zheng,
  • Jiayi Zheng,
  • Yueping Li,
  • Yueping Li,
  • Yueping Li,
  • Xuanjie Chen,
  • Xinyang Zou,
  • Xinyang Zou,
  • Yi Hong,
  • Ke Chen,
  • Ke Chen,
  • Ke Chen,
  • Ke Chen,
  • Yuqi Zeng,
  • Yuqi Zeng,
  • Yuqi Zeng,
  • Qinyong Ye,
  • Qinyong Ye,
  • Qinyong Ye,
  • Xiaochun Chen,
  • Xiaochun Chen,
  • Xiaochun Chen,
  • Xinyan Chen,
  • Xinyan Chen,
  • Xinyan Chen,
  • Yingqing Wang,
  • Yingqing Wang,
  • Yingqing Wang,
  • Guoen Cai,
  • Guoen Cai,
  • Guoen Cai

DOI
https://doi.org/10.3389/fnagi.2023.1304629
Journal volume & issue
Vol. 15

Abstract

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ObjectiveEvidence on the individual and combined relationship of physical activity (PA) and fish oil supplement use on the incidence of Parkinson’s disease (PD) risk remains lacking.Materials and methodsThis UK population-based prospective cohort study, involving 385,275 UK Biobank participants, collected PA and fish oil supplement data via touchscreen questionnaires. Using Cox proportional hazards models and restricted cubic splines to examined the associations between use of fish oil supplements, PA and PD risk.ResultsDuring a median 12.52-year follow-up, 2,131 participants incident PD. Analysis showed that fish oil supplement users had a lower PD risk [hazard ratio (HR), 0.89; 95% confidence interval (CI), 0.82–0.98]. The adjusted HRs for the PD incidence were 0.96 (95% CI, 0.95–0.98) for total PA; 0.93 (95% CI, 0.90–0.96) for moderate PA; 0.95 (95% CI, 0.91–0.99) for vigorous PA and 0.93 (95% CI, 0.89–0.98) for walking activity. Significant interactions were found between fish oil supplement use and total PA (P for interaction = 0.011), moderate PA (P for interaction = 0.015), and walking activity (P for interaction = 0.029) in relation to PD incidence.ConclusionBoth fish oil supplement use and PA were associated with a reduced risk of PD, and the effect of PA in reducing the risk of PD was more pronounced when fish oil supplement was used.

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