Studying some Cytotoxic Parameters of Aspartame (Diet sweet) on Mature Albino Male Mice

Abstract

The present study was planned to evaluate some cytotoxic effect of aspartame intake trough determining the apoptosis cells from peripheral blood and sperm head abnormality from cauda epididymis. After one week of administration of various doses of asparatame (3.5,35,350 mg/kg) to mature albino male mice and distilled water treated group was served as control. The results were statistically analyzed to compare the data of individual dose with that of the control, apoptotic and necrotic cells as well as sperm head are determined. The results showed that induce apoptosis cells in all concentrations (3.5,35,350 mg/kg) and necrotic cells in doses (35, 350 mg/kg) while late apoptosis in doses (35, 3.5 mg/kg) on the other hand, asparatame is increased in sperm head abnormality in (350, 35 mg/kg) dose. According to these results, it was possible to conclude that aspartame have a cytotoxic risk. Therefore, it is necessary to be careful when using such materials in food and beverages as a sweetener.

Keywords

• Apoptosis, Aspartame, cytotoxic, food additives