The range of neurological syndromes associated with glutamic acid decarboxylase antibodies

Abstract

Neurological syndromes caused by production of antibodies toglutamic acid decarboxylase (GAD65) are a relatively new areaof modern clinical neurology, which is of great theoretical andpractical interest. High titer of identified antibodies is a not alwaysspecific, but highly sensitive, marker for autoimmune CNSdisorders. The authors present their own clinical observationsand an analysis of the literature on a wide phenotypic range ofGAD65-associated pathologies.

Keywords

• stiff person syndrome
• sporadic ataxia
• limbic encephalitis
• anti-gad65 antibodies