Biology of Sex Differences (Mar 2023)
CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
- Sebastián Zagmutt,
- Paula Mera,
- Ismael González-García,
- Kevin Ibeas,
- María del Mar Romero,
- Arnaud Obri,
- Beatriz Martin,
- Anna Esteve-Codina,
- M. Carmen Soler-Vázquez,
- Marianela Bastias-Pérez,
- Laia Cañes,
- Elisabeth Augé,
- Carme Pelegri,
- Jordi Vilaplana,
- Xavier Ariza,
- Jordi García,
- José Martinez-González,
- Núria Casals,
- Miguel López,
- Richard Palmiter,
- Elisenda Sanz,
- Albert Quintana,
- Laura Herrero,
- Dolors Serra
Affiliations
- Sebastián Zagmutt
- Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona
- Paula Mera
- Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona
- Ismael González-García
- NeurObesity Group, Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Kevin Ibeas
- Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona
- María del Mar Romero
- Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona
- Arnaud Obri
- Neuronal Control of Metabolism Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Beatriz Martin
- CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology
- Anna Esteve-Codina
- CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology
- M. Carmen Soler-Vázquez
- Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona
- Marianela Bastias-Pérez
- Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona
- Laia Cañes
- Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC)
- Elisabeth Augé
- Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona
- Carme Pelegri
- Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona
- Jordi Vilaplana
- Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona
- Xavier Ariza
- Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III
- Jordi García
- Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III
- José Martinez-González
- Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC)
- Núria Casals
- Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III
- Miguel López
- Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III
- Richard Palmiter
- Department of Biochemistry, Howard Hughes Medical Institute, University of Washington
- Elisenda Sanz
- Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona
- Albert Quintana
- Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona
- Laura Herrero
- Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona
- Dolors Serra
- Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universitat de Barcelona
- DOI
- https://doi.org/10.1186/s13293-023-00498-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 26
Abstract
Highlights Fatty acid metabolism and CPT1A in AgRP neurons show marked sex-dependent differences in the control of feeding. Cpt1a gene deletion in AgRP neurons increases energy expenditure in females but not in males. CPT1A in AgRP neurons is involved in the control of thirst and fluid homeostasis. Cpt1a gene deletion in AgRP neurons induces morphological, mitochondrial, and gene expression alterations in a sex-dependent manner.
Keywords
