Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes

Yanmin Huang; Erbin Kong; Junyan Zhan; Shuang Chen; Chunfang Gan; Zhiping Liu; Liping Pang; Jianguo Cui

doi:10.1155/2017/4276919

Bioinorganic Chemistry and Applications (Jan 2017)

Synthesis and Cytotoxic Evaluation of Steroidal Copper (Cu (II)) Complexes

Yanmin Huang,
Erbin Kong,
Junyan Zhan,
Shuang Chen,
Chunfang Gan,
Zhiping Liu,
Liping Pang,
Jianguo Cui

Affiliations

Yanmin Huang: Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, China
Erbin Kong: Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, China
Junyan Zhan: Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, China
Shuang Chen: Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, China
Chunfang Gan: Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, China
Zhiping Liu: Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, China
Liping Pang: Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, China
Jianguo Cui: Key Laboratory of Beibu Gulf Environment Change and Resources Utilization, College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, China

DOI: https://doi.org/10.1155/2017/4276919
Journal volume & issue: Vol. 2017

Abstract

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Using estrone and pregnenolone as starting materials, some steroidal copper complexes were synthesized by the condensation of steroidal ketones with thiosemicarbazide or diazanyl pyridine and then complexation of steroidal thiosemicarbazones or steroidal diazanyl pyridines with Cu (II). The complexes were characterized by IR, NMR, and HRMS. The synthesized compounds were screened for their cytotoxicity against HeLa, Bel-7404, and 293T cell lines in vitro. The results show that all steroidal copper (II) complexes display obvious antiproliferative activity against the tested cancer cells. The IC50 values of complexes 5 and 12 against Bel-7404 (human liver carcinoma) are 5.0 and 7.0 μM.

Published in Bioinorganic Chemistry and Applications

ISSN: 1565-3633 (Print); 1687-479X (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Chemistry: Inorganic chemistry
Website: https://onlinelibrary.wiley.com/journal/4036

About the journal