Host mRNA Analysis of Periodontal Disease Patients Positive for <i>Porphyromonas gingivalis</i>, <i>Aggregatibacter actinomycetemcomitans</i> and <i>Tannerella forsythia</i>

Abstract

Periodontal disease is a frequent pathology worldwide, with a constantly increasing prevalence. For the optimal management of periodontal disease, there is a need to take advantage of actual technology to understand the bacterial etiology correlated with the pathogenic mechanisms, risk factors and treatment protocols. We analyzed the scientific literature published in the last 5 years regarding the recent applications of mRNA analysis in periodontal disease for the main known bacterial species considered to be the etiological agents: Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia. We identified new pathogenic mechanisms, therapeutic target genes and possible pathways to prevent periodontal disease. The mRNA analysis, as well as the important technological progress in recent years, supports its implementation in the routine management of periodontal disease patients.

Keywords

• biomarkers
• early detection
• cell lines
• animal model
• target therapy
• periodontal disease