Neurobiology of Disease (Jan 1997)
Advances in Charcot–Marie–Tooth Disease Research: Cellular Function of CMT-Related Proteins, Transgenic Animal Models, and Pathomechanisms
- Hans W. Müller,
- Ueli Suter,
- Christine Van Broeckhoven,
- O. Haneman,
- E. Nelis,
- V. Timmerman,
- S. Sancho,
- L. Barrio,
- P. Bolhuis,
- R. Dermietzel,
- M. Frank,
- A. Gabreëls-Festen,
- C. Gillen,
- N. Haites,
- G. Levi,
- E. Mariman,
- R. Martini,
- K. Nave,
- B. Rautenstrauss,
- M. Schachner,
- A. Schenone,
- C. Schneider,
- M. Schröder,
- K. Willecke
Affiliations
- Hans W. Müller
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- Ueli Suter
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- Christine Van Broeckhoven
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- O. Haneman
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- E. Nelis
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- V. Timmerman
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- S. Sancho
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- L. Barrio
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- P. Bolhuis
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- R. Dermietzel
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- M. Frank
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- A. Gabreëls-Festen
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- C. Gillen
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- N. Haites
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- G. Levi
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- E. Mariman
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- R. Martini
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- K. Nave
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- B. Rautenstrauss
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- M. Schachner
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- A. Schenone
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- C. Schneider
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- M. Schröder
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- K. Willecke
- Molecular Neurobiology Laboratory, Department of Neurology, Heinrich-Heine-University, 40225, Düsseldorf, Germany; Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland; The European CMT Consortium, University of Antwerp (UIA), Antwerpen, Belgium
- Journal volume & issue
-
Vol. 4,
no. 3
pp. 215 – 220
Abstract
The First Workshop of the European Consortium on Charcot–Marie–Tooth (CMT) disease brought together neuroscientists, molecular and cell biologists, neuropathologists, neurologists, and geneticists with a common interest in the understanding of the fundamental mechanisms that underlie the pathogenesis of CMT. The interdisciplinary group of 25 expert scientists discussed recent advances in (i) molecular genetics and histopathology of CMT, (ii) development of suitable animal models, (iii) understanding of the cellular function of CMT-related proteins, and (iv) studies using nerve biopsies from CMT patients. In this minireview, we summarize the key findings presented and discuss their impact on CMT research.
