Nature Communications (Jul 2021)

Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors

  • Constantin Cretu,
  • Patricia Gee,
  • Xiang Liu,
  • Anant Agrawal,
  • Tuong-Vi Nguyen,
  • Arun K. Ghosh,
  • Andrew Cook,
  • Melissa Jurica,
  • Nicholas A. Larsen,
  • Vladimir Pena

DOI
https://doi.org/10.1038/s41467-021-24741-1
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition and branch site inactivation.