Nature Communications (Jul 2021)
Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
Abstract
Chemical modulation of intron selection has emerged as a route for cancer therapy. Here, structures of the U2 snRNP’s SF3B module and of prespliceosome- both in complexes with splicing modulators- provide insight into the mechanisms of intron recognition and branch site inactivation.