Fibrous Dysplasia in a Child Patient Treated with Bisphosphonates

Abstract

The main property of bisphosphonates is inhibition of maturation and migration of osteoclasts resulting in decrease bone resorption. This property has been often used in the therapy of bone diseases such as osteoporosis, Paget's disease, or as a part of multiple myeloma or osteolytic metastases treatment.The authors describe the application of the property of bisphosphonates to inhibit bone resorption in the therapy of fibrous dysplasia of lower jaw in a 15-year girl. The treatment used an oral form of alendronate. The course of the disease is documented by scintigraphy images. The fibrous dysplasia has not disappeared completely, but there was a substantial decrease in metabolic activity of the lesion which prevented a superfluous enlargement of the focus and development of deformity of lower jaw.

Keywords

• fibrous dysplasia
• bisphosphonates
• osteoclasts
• osteoporosis
• scintigraphy