Cell Transplantation (Aug 2016)
A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation
- Ling-Jia Wang,
- Tatsuya Kin,
- Doug O'gorman,
- A. M. James Shapiro,
- Bashoo Naziruddin,
- Morihito Takita,
- Marlon F. Levy,
- Andrew M. Posselt,
- Gregory L. Szot,
- Omid Savari,
- Barbara Barbaro,
- James McGarrigle,
- Chun Chieh Yeh,
- Jose Oberholzer,
- Ji Lei,
- Tao Chen,
- Moh Lian,
- James F. Markmann,
- Alejandro Alvarez,
- Elina Linetsky,
- Camillo Ricordi,
- A. N. Balamurugan,
- Gopalakrishnan Loganathan,
- Joshua J. Wilhelm,
- Bernhard J. Hering,
- Rita Bottino,
- Massimo Trucco,
- Chengyang Liu,
- Zaw Min,
- Yanjing Li,
- Ali Naji,
- Luis A. Fernandez,
- Martynas Ziemelis,
- Juan S. Danobeitia,
- J. Michael Millis,
- Piotr Witkowski
Affiliations
- Ling-Jia Wang
- Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL, USA
- Tatsuya Kin
- Clinical Islet Transplant Program, University of Alberta and Alberta Health Services, Edmonton, Alberta, Canada
- Doug O'gorman
- Clinical Islet Transplant Program, University of Alberta and Alberta Health Services, Edmonton, Alberta, Canada
- A. M. James Shapiro
- Clinical Islet Transplant Program, University of Alberta and Alberta Health Services, Edmonton, Alberta, Canada
- Bashoo Naziruddin
- Baylor Simmons Transplant Institute, Dallas, TX, USA
- Morihito Takita
- Baylor Simmons Transplant Institute, Dallas, TX, USA
- Marlon F. Levy
- Baylor Simmons Transplant Institute, Dallas, TX, USA
- Andrew M. Posselt
- UCSF Transplantation Surgery, University of California-San Francisco, San Francisco, CA, USA
- Gregory L. Szot
- UCSF Transplantation Surgery, University of California-San Francisco, San Francisco, CA, USA
- Omid Savari
- Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL, USA
- Barbara Barbaro
- UIC Cell Isolation Program, University of Illinois at Chicago, Chicago, IL, USA
- James McGarrigle
- UIC Cell Isolation Program, University of Illinois at Chicago, Chicago, IL, USA
- Chun Chieh Yeh
- UIC Cell Isolation Program, University of Illinois at Chicago, Chicago, IL, USA
- Jose Oberholzer
- UIC Cell Isolation Program, University of Illinois at Chicago, Chicago, IL, USA
- Ji Lei
- Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, USA
- Tao Chen
- Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, USA
- Moh Lian
- Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, USA
- James F. Markmann
- Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, USA
- Alejandro Alvarez
- Diabetes Research Institute, cGMP Cell Processing Facility, University of Miami Miller School of Medicine, Miami, FL, USA
- Elina Linetsky
- Diabetes Research Institute, cGMP Cell Processing Facility, University of Miami Miller School of Medicine, Miami, FL, USA
- Camillo Ricordi
- Diabetes Research Institute, cGMP Cell Processing Facility, University of Miami Miller School of Medicine, Miami, FL, USA
- A. N. Balamurugan
- Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, USA
- Gopalakrishnan Loganathan
- Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, USA
- Joshua J. Wilhelm
- Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, USA
- Bernhard J. Hering
- Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, USA
- Rita Bottino
- Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, USA
- Massimo Trucco
- Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, USA
- Chengyang Liu
- Division of Transplantation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- Zaw Min
- Division of Transplantation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- Yanjing Li
- Division of Transplantation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- Ali Naji
- Division of Transplantation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
- Luis A. Fernandez
- Division of Organ Transplantation, University of Wisconsin, Madison, WI, USA
- Martynas Ziemelis
- Division of Organ Transplantation, University of Wisconsin, Madison, WI, USA
- Juan S. Danobeitia
- Division of Organ Transplantation, University of Wisconsin, Madison, WI, USA
- J. Michael Millis
- Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL, USA
- Piotr Witkowski
- Department of Surgery, Section of Transplantation, University of Chicago, Chicago, IL, USA
- DOI
- https://doi.org/10.3727/096368916X691141
- Journal volume & issue
-
Vol. 25
Abstract
Selection of an optimal donor pancreas is the first key task for successful islet isolation. We conducted a retrospective multicenter study in 11 centers in North America to develop an islet donor scoring system using donor variables. The data set consisting of 1,056 deceased donors was used for development of a scoring system to predict islet isolation success (defined as postpurification islet yield >400,000 islet equivalents). With the aid of univariate logistic regression analyses, we developed the North American Islet Donor Score (NAIDS) ranging from 0 to 100 points. The c index in the development cohort was 0.73 (95% confidence interval 0.70–0.76). The success rate increased proportionally as the NAIDS increased, from 6.8% success in the NAIDS < 50 points to 53.7% success in the NAIDS ≥ 80 points. We further validated the NAIDS using a separate set of data consisting of 179 islet isolations. A comparable outcome of the NAIDS was observed in the validation cohort. The NAIDS may be a useful tool for donor pancreas selection in clinical practice. Apart from its utility in clinical decision making, the NAIDS may also be used in a research setting as a standardized measurement of pancreas quality.
