Magnetic Resonance Imaging Findings in Infants with Severe Traumatic Brain Injury and Associations with Abusive Head Trauma

Nikki Miller Ferguson; Susan Rebsamen; Aaron S. Field; Jose M. Guerrero; Bedda L. Rosario; Aimee T. Broman; Paul J. Rathouz; Michael J. Bell; Andrew L. Alexander; Peter A. Ferrazzano

doi:10.3390/children9071092

Children (Jul 2022)

Magnetic Resonance Imaging Findings in Infants with Severe Traumatic Brain Injury and Associations with Abusive Head Trauma

Nikki Miller Ferguson,
Susan Rebsamen,
Aaron S. Field,
Jose M. Guerrero,
Bedda L. Rosario,
Aimee T. Broman,
Paul J. Rathouz,
Michael J. Bell,
Andrew L. Alexander,
Peter A. Ferrazzano

Affiliations

Nikki Miller Ferguson: Department of Pediatrics, Virginia Commonwealth University, Richmond, VA 23298, USA
Susan Rebsamen: Department of Radiology, University of Wisconsin, Madison, WI 53792, USA
Aaron S. Field: Department of Radiology, University of Wisconsin, Madison, WI 53792, USA
Jose M. Guerrero: Waisman Center, University of Wisconsin, Madison, WI 53705, USA
Bedda L. Rosario: Department of Epidemiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Aimee T. Broman: Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI 53705, USA
Paul J. Rathouz: Department of Population Health, University of Texas at Austin Dell Medical School, Austin, TX 78712, USA
Michael J. Bell: Department of Pediatrics, Children’s National Medical Center, Washington, DC 20010, USA
Andrew L. Alexander: Waisman Center, University of Wisconsin, Madison, WI 53705, USA
Peter A. Ferrazzano: Waisman Center, University of Wisconsin, Madison, WI 53705, USA

DOI: https://doi.org/10.3390/children9071092
Journal volume & issue: Vol. 9, no. 7
p. 1092

Abstract

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Young children with severe traumatic brain injury (TBI) have frequently been excluded from studies due to age and/or mechanism of injury. Magnetic resonance imaging (MRI) is now frequently being utilized to detect parenchymal injuries and early cerebral edema. We sought to assess MRI findings in infants with severe TBI, and to determine the association between specific MRI findings and mechanisms of injury, including abusive head trauma (AHT). MRI scans performed within the first 30 days after injury were collected and coded according to NIH/NINDS Common Data Elements (CDEs) for Neuroimaging in subjects age p = 0.001) and “inflicted” injury mechanism (p = 0.0003). In conclusion, the most common intracerebral injury seen on MRI of infants with severe TBI was ischemia, followed by contusion and DAI. Ischemia was associated with AHT, and ischemia affecting > 4 brain regions was predictive of AHT.

Published in Children

ISSN: 2227-9067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://www.mdpi.com/journal/children

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Abstract

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