Nature Communications (Feb 2023)
Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas
- Yanming Ren,
- Zongyao Huang,
- Lingling Zhou,
- Peng Xiao,
- Junwei Song,
- Ping He,
- Chuanxing Xie,
- Ran Zhou,
- Menghan Li,
- Xiangqun Dong,
- Qing Mao,
- Chao You,
- Jianguo Xu,
- Yanhui Liu,
- Zhigang Lan,
- Tiejun Zhang,
- Qi Gan,
- Yuan Yang,
- Tengyun Chen,
- Bowen Huang,
- Xiang Yang,
- Anqi Xiao,
- Yun Ou,
- Zhengzheng Su,
- Lu Chen,
- Yan Zhang,
- Yan Ju,
- Yuekang Zhang,
- Yuan Wang
Affiliations
- Yanming Ren
- Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Zongyao Huang
- Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Lingling Zhou
- Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Peng Xiao
- Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Junwei Song
- Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second Hospital, Sichuan University
- Ping He
- Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second Hospital, Sichuan University
- Chuanxing Xie
- Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Ran Zhou
- Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Menghan Li
- Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Xiangqun Dong
- Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- Qing Mao
- Department of Neurosurgery, West China Hospital, Sichuan University
- Chao You
- Department of Neurosurgery, West China Hospital, Sichuan University
- Jianguo Xu
- Department of Neurosurgery, West China Hospital, Sichuan University
- Yanhui Liu
- Department of Neurosurgery, West China Hospital, Sichuan University
- Zhigang Lan
- Department of Neurosurgery, West China Hospital, Sichuan University
- Tiejun Zhang
- Department of Neurosurgery, West China Hospital, Sichuan University
- Qi Gan
- Department of Neurosurgery, West China Hospital, Sichuan University
- Yuan Yang
- Department of Neurosurgery, West China Hospital, Sichuan University
- Tengyun Chen
- Department of Neurosurgery, West China Hospital, Sichuan University
- Bowen Huang
- Department of Neurosurgery, West China Hospital, Sichuan University
- Xiang Yang
- Department of Neurosurgery, West China Hospital, Sichuan University
- Anqi Xiao
- Department of Neurosurgery, West China Hospital, Sichuan University
- Yun Ou
- Department of Pathology, West China Hospital, Sichuan University
- Zhengzheng Su
- Department of Pathology, West China Hospital, Sichuan University
- Lu Chen
- Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, West China Second Hospital, Sichuan University
- Yan Zhang
- National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
- Yan Ju
- Department of Neurosurgery, West China Hospital, Sichuan University
- Yuekang Zhang
- Department of Neurosurgery, West China Hospital, Sichuan University
- Yuan Wang
- Department of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University
- DOI
- https://doi.org/10.1038/s41467-023-36707-6
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 19
Abstract
The spatial organisation of diffuse midline glioma-H3K27M mutant (DMG) and glioblastoma (GBM) remains to be investigated. Here, the authors integrate short-read and long-read spatial profiling of DMG and GBM to identify regulatory programs and cellular ecosystems in distinct glioma niches.
