Studies on Regulation of the Cell Cycle in Fission Yeast

Abstract

Essential for normal life progression and reproduction is correct chromosome segregation during mitosis and meiosis. Defects in the division program lead to aneuploidy, which in turn leads to birth defects, miscarriages or cancer. Although, researchers invented much about the regulation of the cell cycle, there is still long way to understand the complexity of the regulatory machineries that ensure proper segregation of chromosomes. In this paper we show the results of visualization of the cell cycle progression during meiosis and mitosis with the use of live cell imaging microscopy technique. As a model organism we use the fission yeast Schizosaccharomyces pombe.

Keywords

• meiosis
• mitosis
• live cell imaging
• schizosaccharomyces pombe