Nature Communications (Aug 2022)

Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes

  • Parsa Akbari,
  • Olukayode A. Sosina,
  • Jonas Bovijn,
  • Karl Landheer,
  • Jonas B. Nielsen,
  • Minhee Kim,
  • Senem Aykul,
  • Tanima De,
  • Mary E. Haas,
  • George Hindy,
  • Nan Lin,
  • Ian R. Dinsmore,
  • Jonathan Z. Luo,
  • Stefanie Hectors,
  • Benjamin Geraghty,
  • Mary Germino,
  • Lampros Panagis,
  • Prodromos Parasoglou,
  • Johnathon R. Walls,
  • Gabor Halasz,
  • Gurinder S. Atwal,
  • Regeneron Genetics Center,
  • DiscovEHR Collaboration,
  • Marcus Jones,
  • Michelle G. LeBlanc,
  • Christopher D. Still,
  • David J. Carey,
  • Alice Giontella,
  • Marju Orho-Melander,
  • Jaime Berumen,
  • Pablo Kuri-Morales,
  • Jesus Alegre-Díaz,
  • Jason M. Torres,
  • Jonathan R. Emberson,
  • Rory Collins,
  • Daniel J. Rader,
  • Brian Zambrowicz,
  • Andrew J. Murphy,
  • Suganthi Balasubramanian,
  • John D. Overton,
  • Jeffrey G. Reid,
  • Alan R. Shuldiner,
  • Michael Cantor,
  • Goncalo R. Abecasis,
  • Manuel A. R. Ferreira,
  • Mark W. Sleeman,
  • Viktoria Gusarova,
  • Judith Altarejos,
  • Charles Harris,
  • Aris N. Economides,
  • Vincent Idone,
  • Katia Karalis,
  • Giusy Della Gatta,
  • Tooraj Mirshahi,
  • George D. Yancopoulos,
  • Olle Melander,
  • Jonathan Marchini,
  • Roberto Tapia-Conyer,
  • Adam E. Locke,
  • Aris Baras,
  • Niek Verweij,
  • Luca A. Lotta

DOI
https://doi.org/10.1038/s41467-022-32398-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

Fat distribution is associated with cardiometabolic disease, although it has been less well studied than overall obesity. In a multiancestry exome-sequencing study, the authors identified predicted loss-of-function mutations in INHBE associated with favorable fat distribution and protection from type 2 diabetes.