The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices

Yanan Li; Yanan Li; Xin’e Xie; Hang Xing; Hang Xing; Xiang Yuan; Yuan Wang; Yikai Jin; Jiangang Wang; Martin Vreugdenhil; Ying Zhao; Ruiling Zhang; Chengbiao Lu; Chengbiao Lu

doi:10.3389/fncel.2019.00277

Frontiers in Cellular Neuroscience (Jun 2019)

The Modulation of Gamma Oscillations by Methamphetamine in Rat Hippocampal Slices

Yanan Li,
Yanan Li,
Xin’e Xie,
Hang Xing,
Hang Xing,
Xiang Yuan,
Yuan Wang,
Yikai Jin,
Jiangang Wang,
Martin Vreugdenhil,
Ying Zhao,
Ruiling Zhang,
Chengbiao Lu,
Chengbiao Lu

Affiliations

Yanan Li: The Second Affiliated Hospital, Xinxiang Medical University, Xinxiang, China
Yanan Li: Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang, China
Xin’e Xie: Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang, China
Hang Xing: Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang, China
Hang Xing: Department of Neurology, Henan Provincial People’s Hospital, Zhengzhou, China
Xiang Yuan: The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, Luoyang, China
Yuan Wang: Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang, China
Yikai Jin: Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang, China
Jiangang Wang: Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang, China
Martin Vreugdenhil: Department of Health Sciences, Birmingham City University, Birmingham, United Kingdom
Ying Zhao: Key Laboratory of Clinical Psychopharmacology, School of Pharmacy, Xinxiang Medical University, Xinxiang, China
Ruiling Zhang: The Second Affiliated Hospital, Xinxiang Medical University, Xinxiang, China
Chengbiao Lu: The Second Affiliated Hospital, Xinxiang Medical University, Xinxiang, China
Chengbiao Lu: Key Laboratory for the Brain Research of Henan Province, Department of Physiology, Xinxiang Medical University, Xinxiang, China

DOI: https://doi.org/10.3389/fncel.2019.00277
Journal volume & issue: Vol. 13

Abstract

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Gamma frequency oscillations (γ, 30–100 Hz) have been suggested to underlie various cognitive and motor functions. The psychotomimetic drug methamphetamine (MA) enhances brain γ oscillations associated with changes in psychomotor state. Little is known about the cellular mechanisms of MA modulation on γ oscillations. We explored the effects of multiple intracellular kinases on MA modulation of γ induced by kainate in area CA3 of rat ventral hippocampal slices. We found that dopamine receptor type 1 and 2 (DR1 and DR2) antagonists, the serine/threonine kinase PKB/Akt inhibitor and N-methyl-D-aspartate receptor (NMDAR) antagonists prevented the enhancing effect of MA on γ oscillations, whereas none of them affected baseline γ strength. Protein kinase A, phosphoinositide 3-kinase and extracellular signal-related kinases inhibitors had no effect on MA. We propose that the DR1/DR2-Akt-NMDAR pathway plays a critical role for the MA enhancement of γ oscillations. Our study provides an new insight into the mechanisms of acute MA on MA-induced psychosis.

Published in Frontiers in Cellular Neuroscience

ISSN: 1662-5102 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/cellular-neuroscience

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